The ORL explores ways of exploiting non-invasive optical measurements for both functional and molecular biological imaging. Specifically, we develop subsurface optical tomography for imaging intrinsic, hemoglobin-sensitive contrasts, and exogenous, molecularly-targeted-fluorescent contrasts. Using hemoglobin contrasts, a portable and wearable brain imaging device is being developed to expand the range of human behaviors that can be assessed with functional neuroimaging techniques. In another project, fluorescence tomography systems and methods are being developed to image the bio-distribution of molecularly targeted probes in small animal models of disease.
ORL's recent breakthroughs:
The fluorescence goggle system developed by ORL was used for image guided biopsy of the sentinel lymph node in a breast cancer patient.
The brain imaging system developed by the ORL has been in the news lately. "It has been 20 years since near-infrared spectroscopy was first used to investigate human brain function. The technique has subsequently been extended to offer high-resolution imaging of the cortex and has now become a viable alternative to functional magnetic resonance imaging." Cooper, Nature Photonics News and Views.