Welcome to the Optical Radiology Lab!
The Optical Radiology Lab harnesses the power of light to develop methods for understanding, diagnosing and treating human diseases. Our interdisciplinary and collaborative team of biologist, chemists, engineers, medical scientists and physicists are focused on uncovering new frontiers in medical research. The unique strength of the ORL is the ability to develop complete solutions from conception, implementation, and validation to human clinical care. We aim to change the way medicine is practiced.
Using a mouse model of cancer, the Achilefu Lab have devised a way to apply light-based therapy to deep tissues never before accessible. Instead of shining an outside light, they delivered light directly to tumor cells, along with a photosensitive source of free radicals that can be activated by the light to destroy cancer. And they accomplished this using materials already approved for use in cancer patients. The study appears March 9 in the journal Nature Nanotechnology. Congratulations to the authors - Samuel Achilefu, Nalinikanth Kotagiri, Gail Sudlow and Walter Akers!
The titanium dioxide nanoparticle is shown here (purple)
carrying the iron-binding protein transferrin (blue and green)
and the light-sensitive cancer drug titanocene (red).