Optical Radiology Labs at Washington University in St. Louis School of Medicine


Welcome to the Optical Radiology Lab!

The ORL explores ways of exploiting non-invasive optical measurements for both functional and molecular biological imaging. Specifically, we develop subsurface optical tomography for imaging intrinsic, hemoglobin-sensitive contrasts, and exogenous, molecularly-targeted-fluorescent contrasts. Using hemoglobin contrasts, a portable and wearable brain imaging device is being developed to expand the range of human behaviors that can be assessed with functional neuroimaging techniques. In another project, fluorescence tomography systems and methods are being developed to image the bio-distribution of molecularly targeted probes in small animal models of disease.


In the news!

  • Dr. Achilefu receives prestigious St. Louis Award ​​​for cancer goggles

Washington University Chancellor Emeritus William H. Danforth (left) visits with Samuel Achilefu, PhD, after Achilefu received the St. Louis Award on Wednesday, Jan. 14, on the Medical Campus. The honor recognizes area residents whose achievements reflect positively on the community. Danforth received the honor in 2012.

  • The fluorescence goggle system developed by ORL was used for image guided biopsy of the sentinel lymph node in a breast cancer patient.


  • The brain imaging system developed by the ORL has been in the news lately. "It has been 20 years since near-infrared spectroscopy was first used to investigate human brain function. The technique has subsequently been extended to offer high-resolution imaging of the cortex and has now become a viable alternative to functional magnetic resonance imaging." Cooper, Nature Photonics News and Views.

ORL Updates:
Dr. Achilefu named recipient of The St. Louis Award.

HD-DOT System in the news!
Optical brain scanner goes where other brain scanners can’t

2014 OSA Poster Winners
Mahlega Hassanpour and Patrick Wright Win OSA Poster Awards

©2011 Mallinckrodt Institute of Radiology     Last Modified on January 27th