Optical Radiology Labs at Washington University in St. Louis School of Medicine
Brian R. White

Brian R. White

Graduate Student, Dept. of Physics
Medical Student
4525 Scott Avenue
Campus Box 8225
St. Louis, MO 63110


  • Harvard University, Cambridge, MA 2000-2004 BA, Physics

Research Interests

Functional neuroimaging (e.g, with fMRI and PET) has become an important part of neuroscience research. However, the use of these tools in clinical environments has been hampered by such limitations as the need to sedate children before scans and the inability to transport intensive care patients to fixed scanners. Functional imaging through Diffuse Optical Tomography (DOT, which measures blood content and oxygenation using infrared light through the same principle as a pulse oximeter) has the potential to supplement current imaging technologies and be an important clinical tool. In the lab of Dr. Joseph Culver, I work on many aspects of DOT development including engineering the system and developing more advanced imaging algorithms. Current imaging projects include mapping retinotopy in the adult visual cortex and measuring resting-state functional connectivity.


  • White BR and Culver JP. A quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance. Journal of Biomedical Optics, In Press (2010).
  • White BR and Culver JP. Phase-encoded retinotopy as an evaluation of diffuse optical neuroimaging. Neuroimage 49 (2010), 568-577.
  • White BR, Synder AZ, Cohen AL, Petersen SE, Raichle ME, Schlaggar BL, and Culver JP. Resting-state functional connectivity in the human brain revealed with diffuse optical tomography. Neuroimage 47 (2009), 148-156.
  • White BR, Pierce MC, Nassif N, Cense B, Park BH, Tearney GJ, Bouma BE, Chen TC, and de Boer JF. In vivo dyhamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography. Optics Express 11 (2003), 3490-3497.
  • Zeff BW, White BR, Dehghani H, Schlaggar BL, and Culver JP. Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography. Proc Natl Acad Sci USA 104 (2007), 12169-74.
  • Markham J, White BR, Zeff BW, and Culver JP. Blind identification of evoked human brain activity with independent component analysis of optical data. Human Brain Mapping 30 (2009), 2382-2392.
  • Dehghani H, White BR, Zeff BW, Tizzard A, and Culver JP. Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography. Applied Optics 48 (2009), D137-D143.
  • Chen TC, Cense B, Pierce MC, Nassif N, Park BH, Yun, SH, White BR, Bouma BE, Tearney GJ, and de Boer JF. Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging. Archives of Ophthalmology 123 (2005), 1715-1720.
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