Dr. Shokeen’s projects include development and evaluation of small- and macro-molecular agents for multi-modal molecular imaging of cancer and cardiovascular diseases. Dr. Shokeen has designed in vitro cell assays to screen novel cell surface receptor targeted constructs including nanoparticles to investigate ligand-receptor structure-activity relationships in biologically relevant environments. The in vitro evaluations are a key bridge to in vivo applications in her research. One of Dr. Shokeen’s cancer imaging projects involve development and evaluation of very late antigen-4 (VLA-4) targeted PET radiopharmaceuticals for non- invasive molecular imaging of multiple myeloma. She recently published her findings involving the molecular imaging of hematopoietic progenitor cells (HPCs) that localize in the pre-metastatic niche prior to migration of tumor cells in metastatic mouse models of breast cancer. Dr. Shokeen’s projects seek to bring in the strengths of PET, MRI and Optical imaging techniques. In one of her cardiac imaging projects, Dr. Shokeen is using tomographic optical modalities for targeted molecular imaging of atherosclerotic plaques in pre-clinical animal models. Dr. Shokeen has active clinical collaborations within the oncology, cardiology and pathology departments.
Dr. Shokeen is passionately involved in designing and teaching interdisciplinary courses focused on imaging sciences and nanomedicine. She is currently the course master for the Principles and Applications in Biological Imaging (PABI) course.
For an up to date list of Dr. Shokeen's publications please see her entry on PubMed.