Optical Radiology Labs at Washington University in St. Louis School of Medicine
Sharon Bloch

Sharon Bloch

Senior Scientist
(314) 747-0699
BLOCHS@WUSTL.EDU
Washington University School of Medicine
Department of Radiology
Campus Box 8225
4525 Scott Avenue

Education

  • PhD, Cellular and Molecular Biology, Saint Louis University, St. Louis, MO 1996
  • BS, Biology and Chemistry, Millikin University, Decatur, IL 1985

Research Interests

Regulation of differential gene expression, particularly in tumors and during development.

Publications

  • Edwards WB, Akers WJ, Ye YP, et al. Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic-RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide. 2009. 8(2): 101-110.
  • Achilefu S, Berezin M, Akers W, et al. ANYL 272-Fluorescence lifetime imaging of tumors using near infrared fluorescent molecular probes. Abstracts of Papers of the American Chemical Society. 2008 236
  • Ye Y, Bloch S, Xu B, Achilefu S. Novel near-infrared fluorescent integrin-targeted DFO analogue. Bioconjub. Chem. 2008 Jan; 19 (1): 225-34.
  • Bloch S, Xu B, Ye Y, Liang K, Nikiforovich GV, Achilefu S. The linear grd peptide labeled with a fluorescent probe interacts with beta-3 integrin. 2006 J Peptide Sci 12: 230 (Suppl. S).
  • Patwardahan SV, Bloch S, Achilefu S, Culver JP. Quantitative small animal fluorescence tomography using an ultrafast gated image intensifier. Conf Proc IEEE Eng. Med. Biol. Soc. 2006 1: 2675-8.
  • Bloch S, Xu B, Ye Y, Liang K, Nikiforovich GV, Achilefu S. Targeting Beta-3 integrin using a linear hexapeptide labeled with near-infrared fluorescent molecular probe. Mol Pharm. 2006 Sep-Oct; 3(5): 539-49.
  • Ye Y, Bloch S, Xu B, Achilefu S. Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7): 2268-75.
  • Bloch S, Lesage F, McIntosh L, Gandjbakhche A, Liang K, Achilefu S. Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice. J Biomed Opt. 2005 Sep-Oct; 10(5):054003.
  • Zhang Z, Liang K, Bloch S, Berezin M, Achilefu S. Monomolecular multimodal fluorescence-radioisotope imaging agents. Bioconj Chem. 2005 Sep-Oct; 16(5): 1232-9.
  • Achilefu S, Bloch S, Markiewicz MA, Zhong T, Ye y, Dorshow RB, Chance B, Liang K. Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression. Proc Natl Acad Sce USA. 2005 May 31; 102(22): 7976-81.
  • Patwardhan SV, Bloch SR, Achilefu S, Culver JP. Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Optics Express 2005 April 4; 13(7): 2564-77.
  • Achilefu S, Ye YP, Bloch S, Zhang ZR, Berezin M, Liang KX. Development of contrast effectors for optical and multimodal imaging of tumors. Abstracts of Papers of the American Chemical Society. 2004 228: U824.
  • Ye Y, Bloch S, Kao J, Achilefu S. Multivalent carbocyanine molecular probes: synthesis and applications. Bioconjug. Chem. 2005 Jan-Feb; 16(1): 51-61.
  • Ye Y, Bloch S, Achilefu S. Ployvalent carbocyanine molecular beacons for molecular recgonitions. J Am

Hobbies

I’ve run 3 full marathons and am currently working with a swimming coach to help me reach my goal of completing a half-Ironman triathlon. I play both the accordion and the harp. I also like to knit and read trashy novels.

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